Short peptides are important molecules found in foods and biological samples that play essential roles in biological processes and food functionality. However, determining their amino acid sequences has been challenging using conventional methods.
A research team led by Associate Professor Mitsuru Tanaka (Faculty of Agriculture), a member of the Environment and Food Unit and the Sustainable Food Resource Design Program, has established a novel peptidomics technology that applies a coumarin derivatization mass spectrometry (MS) method to MS/MS analysis. This approach enables the direct sequencing of low-molecular-weight peptides from mass spectrometry data without relying on existing sequence databases.
This technology is expected to contribute to the functional evaluation of foods, the discovery of bioactive peptides, and the identification of disease-associated peptides.
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