{"id":6325,"date":"2026-08-19T23:55:21","date_gmt":"2026-08-19T14:55:21","guid":{"rendered":"https:\/\/in2fs.kyushu-u.ac.jp\/?p=6325"},"modified":"2026-08-20T10:43:29","modified_gmt":"2026-08-20T01:43:29","slug":"notice-research-associate-prof-fukuda-20260819","status":"publish","type":"post","link":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/news\/notice-research-associate-prof-fukuda-20260819\/","title":{"rendered":"75\u6b73\u4ee5\u4e0a\u306e2\u578b\u7cd6\u5c3f\u75c5\u3001SGLT2\u963b\u5bb3\u85ac\u3067\u6b7b\u4ea1\u30fb\u900f\u6790\u30ea\u30b9\u30af\u304c\u4f4e\u3044\u53ef\u80fd\u6027\uff1a500\u4e07\u4eba\u898f\u6a21\u306e\u533b\u7642\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u304b\u3089"},"content":{"rendered":"<div class=\"u-show-for-ja\" lang=\"ja\" data-modified=\"2026-08-21\">\n\u91ce\u9593\u4e45\u53f2 \u7d71\u8a08\u6570\u7406\u7814\u7a76\u6240\uff0f\u7dcf\u5408\u7814\u7a76\u5927\u5b66\u9662\u5927\u5b66\u6559\u6388\u3001\u5f8c\u85e4\u6e29 \u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u533b\u5b66\u90e8\u6559\u6388\u3001<strong>\u798f\u7530\u6cbb\u4e45 \u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662\u51c6\u6559\u6388<\/strong><a href=\"https:\/\/in2fs.kyushu-u.ac.jp\/unit\/medicine-and-health\/\">\uff08\u533b\u7642\u30fb\u5065\u5eb7\u30e6\u30cb\u30c3\u30c8\/\u793e\u4f1a\u5909\u9769\u578b\u30c7\u30fc\u30bf\u30b5\u30a4\u30a8\u30f3\u30b9\u30b0\u30eb\u30fc\u30d7\u30e1\u30f3\u30d0\u30fc\uff09<\/a>\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u300175\u6b73\u4ee5\u4e0a\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308bSGLT2\u963b\u5bb3\u85ac<strong>\u203b1<\/strong>\u307e\u305f\u306fDPP-4\u963b\u5bb3\u85ac<strong>\u203b2<\/strong>\u306e\u4f7f\u7528\u304c\u3001\u6b7b\u4ea1\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u814e\u75be\u60a3\u306a\u3069\u306e\u30ea\u30b9\u30af\u3068\u3069\u306e\u3088\u3046\u306b\u95a2\u9023\u3059\u308b\u304b\u3092\u5206\u6790\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u300075\u6b73\u4ee5\u4e0a\u306e\u9ad8\u9f62\u8005\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u306b\u52a0\u3048\u3066\u3001\u5fc3\u75be\u60a3\u3001\u814e\u6a5f\u80fd\u4f4e\u4e0b\u3001\u8133\u5352\u4e2d\u3001\u30d5\u30ec\u30a4\u30eb\u306a\u3069\u8907\u6570\u306e\u5065\u5eb7\u554f\u984c\u3092\u62b1\u3048\u308b\u3053\u3068\u304c\u591a\u3044\u305f\u3081\u3001\u30e9\u30f3\u30c0\u30e0\u5316\u81e8\u5e8a\u8a66\u9a13<strong>\u203b3<\/strong>\u306b\u542b\u3081\u308b\u3053\u3068\u304c\u96e3\u3057\u304f\u3001\u65e5\u5e38\u8a3a\u7642\u3067\u3069\u306e\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u3092\u9078\u629e\u3059\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u306e\u304b\u306b\u3064\u3044\u3066\u306e\u76f4\u63a5\u7684\u306a\u79d1\u5b66\u7684\u6839\u62e0\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u65e5\u672c\u306e\u81ea\u6cbb\u4f53\u304c\u4fdd\u6709\u3059\u308b\u533b\u7642\u30fb\u5065\u8a3a\u60c5\u5831\u3092\u7d71\u5408\u3057\u305f500\u4e07\u4eba\u898f\u6a21\u306e\u5927\u898f\u6a21\u533b\u7642\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3067\u3042\u308bLIFE Study<strong>\u203b4<\/strong>\u3092\u3082\u3068\u306b\u3001\u6700\u65b0\u306e\u30c7\u30fc\u30bf\u30b5\u30a4\u30a8\u30f3\u30b9\u306e\u65b9\u6cd5\u3067\u3042\u308b\u6a19\u7684\u8a66\u9a13\u30a8\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3<strong>\u203b5<\/strong>\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u300075\u6b73\u4ee5\u4e0a\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u80058,486\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001SGLT2\u963b\u5bb3\u85ac\u3092\u65b0\u305f\u306b\u958b\u59cb\u3057\u305f2,204\u4eba\u3068\u3001DPP-4\u963b\u5bb3\u85ac\u3092\u65b0\u305f\u306b\u958b\u59cb\u3057\u305f6,282\u4eba\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001SGLT2\u963b\u5bb3\u85ac\u3092\u958b\u59cb\u3057\u305f\u7fa4\u3067\u306f\u3001DPP-4\u963b\u5bb3\u85ac\u3092\u958b\u59cb\u3057\u305f\u7fa4\u306b\u6bd4\u3079\u3001\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u304c\u76f8\u5bfe\u7684\u306b\u7d0432\uff05\u4f4e\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u30cf\u30b6\u30fc\u30c9\u6bd4<strong>\u203b6<\/strong>\u306f0.677\u300195\uff05\u4fe1\u983c\u533a\u9593\u306f0.500\u20130.916\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u672b\u671f\u814e\u4e0d\u5168\u307e\u305f\u306f\u900f\u6790\u5c0e\u5165\u306e\u30ea\u30b9\u30af\u3082\u3001SGLT2\u963b\u5bb3\u85ac\u7fa4\u3067\u306f\u76f8\u5bfe\u7684\u306b\u7d0463\uff05\u4f4e\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u3068\u5fc3\u7b4b\u6897\u585e\u306b\u3064\u3044\u3066\u306f\u3001\u4e3b\u8981\u89e3\u6790\u3067\u4e21\u7fa4\u306e\u9593\u306b\u660e\u78ba\u306a\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u8133\u5352\u4e2d\u306fSGLT2\u963b\u5bb3\u85ac\u7fa4\u3067\u591a\u304f\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u306f\u3001\u2fbc\u9f62\u8005\u306b\u304a\u3051\u308b\u6cbb\u7642\u85ac\u306e\u9078\u629e\u304c\u4e88\u5f8c\u306b\u5f71\u97ff\u3059\u308b\u53ef\u80fd\u6027\u3092\u2f70\u3057\u3001\u81e8\u5e8a\u73fe\u5834\u3067\u306e\u6cbb\u7642\u2f45\u91dd\u6c7a\u5b9a\u306b\u91cd\u8981\u306a\u77e5\u2f92\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>\u3000\u672c\u7814\u7a76\u6210\u679c\u306f\u30012026\u5e748\u670819\u65e5\u306b\u8001\u5e74\u533b\u5b66\u5206\u91ce\u306e\u56fd\u969b\u5b66\u8853\u8a8c\u300cAge and Ageing\u300d\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p><strong>\u3010\u7528\u8a9e\u89e3\u8aac\u3011<\/strong><\/p>\n<p> <strong>\u203b1SGLT2\u963b\u5bb3\u85ac\uff08sodium\u2013glucose cotransporter 2 inhibitors\uff09<\/strong>\uff1a\u814e\u81d3\u3067\u7cd6\u304c\u8840\u6db2\u4e2d\u306b\u518d\u5438\u53ce\u3055\u308c\u308b\u50cd\u304d\u3092\u6291\u3048\u3001\u5c3f\u4e2d\u3078\u306e\u7cd6\u306e\u6392\u51fa\u3092\u5897\u3084\u3059\u3053\u3068\u3067\u8840\u7cd6\u5024\u3092\u4e0b\u3052\u308b\u85ac\u3067\u3059\u3002\u5fc3\u4e0d\u5168\u3084\u814e\u75be\u60a3\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u52b9\u679c\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u8131\u6c34\u3001\u6027\u5668\u611f\u67d3\u75c7\u306a\u3069\u306b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p><strong>\u203b2 DPP-4\u963b\u5bb3\u85ac\uff08dipeptidyl peptidase-4 inhibitors\uff09<\/strong>\uff1a\u8840\u7cd6\u5024\u306b\u5fdc\u3058\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u5206\u6ccc\u3092\u4fc3\u3059\u6d88\u5316\u7ba1\u30db\u30eb\u30e2\u30f3\u306e\u50cd\u304d\u3092\u4fdd\u3064\u3053\u3068\u3067\u3001\u8840\u7cd6\u5024\u3092\u4e0b\u3052\u308b\u85ac\u3067\u3059\u3002\u5358\u72ec\u3067\u306f\u4f4e\u8840\u7cd6\u3092\u8d77\u3053\u3057\u306b\u304f\u304f\u3001\u6bd4\u8f03\u7684\u4f7f\u7528\u3057\u3084\u3059\u3044\u3053\u3068\u304b\u3089\u3001\u65e5\u672c\u306e\u9ad8\u9f62\u8005\u306b\u5e83\u304f\u51e6\u65b9\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p> <strong>\u203b3\u30e9\u30f3\u30c0\u30e0\u5316\u81e8\u5e8a\u8a66\u9a13\uff08randomized clinical trial\uff09<\/strong>\uff1a\u53c2\u52a0\u8005\u3092\u30e9\u30f3\u30c0\u30e0\u306b\u8907\u6570\u306e\u6cbb\u7642\u7fa4\u3078\u5272\u308a\u4ed8\u3051\u3001\u6cbb\u7642\u52b9\u679c\u3092\u6bd4\u8f03\u3059\u308b\u81e8\u5e8a\u8a66\u9a13\u3067\u3059\u3002\u60a3\u8005\u80cc\u666f\u306e\u504f\u308a\u3092\u6291\u3048\u3001\u85ac\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u3046\u3048\u3067\u4fe1\u983c\u6027\u304c\u9ad8\u3044\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\u306e\u4e00\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p> <strong>\u203b4LIFE Study<\/strong>\uff1a\u81ea\u6cbb\u4f53\u304c\u4fdd\u6709\u3059\u308b\u4fdd\u5065\u30fb\u533b\u7642\u30fb\u4ecb\u8b77\u30c7\u30fc\u30bf\u3092\u500b\u4eba\u5358\u4f4d\u3067\u7d71\u5408\u3057\u300120\u5e74\u9593\u3092\u8ffd\u8de1\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u305f\u5927\u898f\u6a21\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u3059\u3002\u4e5d\u5dde\u5927\u5b66\u3068\u306e\u5951\u7d04\u7de0\u7d50\u306b\u3088\u308a\u5b66\u8853\u5229\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u672c\u7814\u7a76\u3067\u306f\u7d71\u8a08\u6570\u7406\u7814\u7a76\u6240\u3068\u4e5d\u5dde\u5927\u5b66\u3068\u306e\u5951\u7d04\u7de0\u7d50\u306b\u3088\u308a\u30c7\u30fc\u30bf\u5229\u7528\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002LIFE Study\u306e\u8a73\u7d30\u306f\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u3092\u53c2\u7167\u304f\u3060\u3055\u3044\uff08<a href=\"https:\/\/life.lifestudylab.org\/\" rel=\"noopener\" target=\"_blank\">https:\/\/life.lifestudylab.org\/<\/a>\uff09\u3002<\/p>\n<p> <strong>\u203b5\u6a19\u7684\u8a66\u9a13\u30a8\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\uff08target trial emulation\uff09<\/strong>\uff1a\u30ea\u30a2\u30eb\u30ef\u30fc\u30eb\u30c9\u306e\u8a3a\u7642\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3001\u300c\u7406\u60f3\u7684\u306a\u30e9\u30f3\u30c0\u30e0\u5316\u81e8\u5e8a\u8a66\u9a13\u3092\u884c\u3046\u3068\u3059\u308c\u3070\u3001\u8ab0\u3092\u5bfe\u8c61\u3068\u3057\u3001\u3044\u3064\u6cbb\u7642\u3092\u958b\u59cb\u3057\u3001\u4f55\u3068\u4f55\u3092\u6bd4\u8f03\u3057\u3001\u3069\u306e\u6642\u70b9\u304b\u3089\u8ffd\u8de1\u3059\u308b\u304b\u300d\u3092\u3042\u3089\u304b\u3058\u3081\u660e\u78ba\u306b\u5b9a\u3081\u3001\u305d\u306e\u8a66\u9a13\u3092\u53ef\u80fd\u306a\u9650\u308a\u30c7\u30fc\u30bf\u4e0a\u3067\u518d\u73fe\u3059\u308b\u65b9\u6cd5\u3067\u3059\u3002\u60a3\u8005\u80cc\u666f\u306e\u9055\u3044\u306a\u3069\u306b\u3088\u308b\u30d0\u30a4\u30a2\u30b9\u3092\u6e1b\u3089\u3057\u3001\u6cbb\u7642\u52b9\u679c\u306b\u95a2\u3059\u308b\u56e0\u679c\u7684\u306a\u554f\u3044\u3092\u691c\u8a0e\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/p>\n<p><strong> \u203b6\u30cf\u30b6\u30fc\u30c9\u6bd4\u30fb95\uff05\u4fe1\u983c\u533a\u9593\uff08hazard ratio; HR\u300195% confidence interval; CI\uff09<\/strong>\uff1a\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f\u3001\u8ffd\u8de1\u671f\u9593\u4e2d\u306b\u6b7b\u4ea1\u3084\u75c5\u6c17\u306a\u3069\u306e\u30a4\u30d9\u30f3\u30c8\u304c\u767a\u751f\u3059\u308b\u901f\u3055\u30922\u7fa4\u3067\u6bd4\u8f03\u3059\u308b\u6307\u6a19\u3067\u3059\u30021\u3088\u308a\u5c0f\u3055\u3044\u5834\u5408\u306f\u6bd4\u8f03\u5bfe\u8c61\u7fa4\u3088\u308a\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u30011\u3088\u308a\u5927\u304d\u3044\u5834\u5408\u306f\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u300295\uff05\u4fe1\u983c\u533a\u9593\u306f\u3001\u63a8\u5b9a\u5024\u306b\u3069\u306e\u7a0b\u5ea6\u306e\u7d71\u8a08\u5b66\u7684\u306a\u4e0d\u78ba\u5b9f\u6027\u304c\u3042\u308b\u304b\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n<p><strong>\u3010\u8ad6\u6587\u60c5\u5831\u3011<\/strong><\/p>\n<p>\u30bf\u30a4\u30c8\u30eb\uff1a   Real-world effectiveness of SGLT2 inhibitors in adults aged 75 years or older: a target trial emulation<br \/>\n\uff0875\u6b73\u4ee5\u4e0a\u306e\u6210\u4eba\u306b\u304a\u3051\u308bSGLT2\u963b\u5bb3\u85ac\u306e\u30ea\u30a2\u30eb\u30ef\u30fc\u30eb\u30c9\u3067\u306e\u6709\u52b9\u6027\uff1a\u6a19\u7684\u8a66\u9a13\u30a8\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\uff09<br \/>\n\u8457\u8005\uff1a      \u91ce\u9593\u4e45\u53f2\u3001\u5f8c\u85e4\u6e29\u3001\u6749\u672c\u5927\u8cb4\u3001\u7802\u7530\u5bdb\u53f8\u3001\u5c0f\u7530\u592a\u53f2\u3001\u524d\u7530\u6075\u3001\u798f\u7530\u6cbb\u4e45<br \/>\n\u63b2\u8f09\u8a8c\uff1a   Age and Ageing<br \/>\nDOI\uff1a     10.1093\/ageing\/afag246\u3000\uff08\u30ea\u30f3\u30af\u306f<a href=\"https:\/\/academic.oup.com\/ageing\/article-abstract\/55\/8\/afag246\/8763887?redirectedFrom=fulltext&amp;login=true\" title=\"https:\/\/academic.oup.com\/ageing\/article-abstract\/55\/8\/afag246\/8763887?redirectedFrom=fulltext&amp;login=true\" rel=\"noopener\" target=\"_blank\">\u3053\u3061\u3089<\/a>\uff09<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u91ce\u9593\u4e45\u53f2 \u7d71\u8a08\u6570\u7406\u7814\u7a76\u6240\uff0f\u7dcf\u5408\u7814\u7a76\u5927\u5b66\u9662\u5927\u5b66\u6559\u6388\u3001\u5f8c\u85e4\u6e29 \u6a2a\u6d5c\u5e02\u7acb\u5927\u5b66\u533b\u5b66\u90e8\u6559\u6388\u3001\u798f\u7530\u6cbb\u4e45 \u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662\u51c6\u6559\u6388\uff08\u533b\u7642\u30fb\u5065\u5eb7\u30e6\u30cb\u30c3\u30c8\/\u793e\u4f1a\u5909\u9769\u578b\u30c7\u30fc\u30bf\u30b5\u30a4\u30a8\u30f3\u30b9\u30b0\u30eb\u30fc\u30d7\u30e1\u30f3\u30d0\u30fc\uff09\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u300175\u6b73\u4ee5\u4e0a\u306e 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