{"id":3068,"date":"2024-11-18T13:41:14","date_gmt":"2024-11-18T04:41:14","guid":{"rendered":"https:\/\/in2fs.kyushu-u.ac.jp\/?p=3068"},"modified":"2024-11-18T13:41:14","modified_gmt":"2024-11-18T04:41:14","slug":"researches1108","status":"publish","type":"post","link":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/news\/researches1108\/","title":{"rendered":"GFAP\u907a\u4f1d\u5b50\u306e\u5909\u7570\u304c\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u306b\u95a2\u308f\u308b\u5927\u8133\u767d\u8cea\u75c5\u5909\u306b\u5f71\u97ff"},"content":{"rendered":"<div class=\"u-show-for-ja\" lang=\"ja\" data-modified=\"2024-11-18\">\n\u672a\u6765\u793e\u4f1a\u30c7\u30b6\u30a4\u30f3\u7d71\u62ec\u672c\u90e8\u3001<a href=\"https:\/\/in2fs.kyushu-u.ac.jp\/unit\/medicine-and-health\/\/\">\u533b\u7642\u30fb\u5065\u5eb7\u30e6\u30cb\u30c3\u30c8\/\u793e\u4f1a\u5909\u9769\u578b\u30c7\u30fc\u30bf\u30b5\u30a4\u30a8\u30f3\u30b9<\/a>\u3000\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\u3001<br \/>\n<strong>\u4e8c\u5bae\u5229\u6cbb\u6559\u6388<\/strong>\uff08\u533b\u5b66\u7814\u7a76\u9662\uff09\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u6210\u679c\u306b\u3064\u3044\u3066\u304a\u77e5\u3089\u305b\u3044\u305f\u3057\u307e\u3059\u3002<br \/>\n<span><br \/>\n\u3000\u5927\u8133\u767d\u8cea\u75c5\u5909\u306f\u8133MRI\u753b\u50cf\u3067\u3088\u304f\u898b\u3089\u308c\u308b\u75c5\u5909\u3067\u3001\u8133\u5352\u4e2d\u3084\u8a8d\u77e5\u75c7\u306e\u767a\u75c7\u306b\u95a2\u308f\u308b\u91cd\u8981\u306a\u6240\u898b\u3067\u3059\u3002\u5927\u8133\u767d\u8cea\u75c5\u5909\u306f\u9ad8\u8840\u5727\u306a\u3069\u306e\u751f\u6d3b\u7fd2\u6163\u75c5\u304c\u3042\u308b\u3068\u51fa\u73fe\u3057\u3084\u3059\u3044\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u907a\u4f1d\u7684\u8981\u56e0\u3082\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u5927\u8133\u767d\u8cea\u75c5\u5909\u306b\u5f71\u97ff\u3059\u308b\u907a\u4f1d\u8981\u56e0\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u30a2\u30b8\u30a2\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3082\u306e\u306f\u6570\u767e\u4eba\u7a0b\u5ea6\u3067\u306e\u5c0f\u898f\u6a21\u306a\u89e3\u6790\u306b\u9650\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\n\u3000\u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662 \u885b\u751f\u30fb\u516c\u8846\u885b\u751f\u5b66\u5206\u91ce\u306e\u4e8c\u5bae\u5229\u6cbb\u6559\u6388\u3001\u75c5\u614b\u6a5f\u80fd\u5185\u79d1\u5b66\u306e\u53e4\u7530\u82b3\u5f66\u52a9\u6559\u3001\u773c\u75c5\u614b\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u8b1b\u5ea7\u306e\u79cb\u5c71\u96c5\u4eba\u8b1b\u5e2b\u3001\u304a\u3088\u3073\u5f18\u524d\u5927\u5b66\u3001\u5ca9\u624b\u533b\u79d1\u5927\u5b66\u3001\u91d1\u6ca2\u5927\u5b66\u3001\u6176\u61c9\u7fa9\u587e\u5927\u5b66\u3001\u677e\u6c5f\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u3001\u611b\u5a9b\u5927\u5b66\u3001\u718a\u672c\u5927\u5b66\u3001\u6771\u5317\u5927\u5b66\u3001\u7406\u5316\u5b66\u7814\u7a76\u6240\u751f\u547d\u533b\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3089\u306e\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u5065\u5eb7\u9577\u5bff\u793e\u4f1a\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u305f\u5927\u898f\u6a21\u8a8d\u77e5\u75c7\u30b3\u30db\u30fc\u30c8\u7814\u7a76\uff1aJPSC-AD\u7814\u7a76\u306e\u53c2\u52a0\u80059,479\u4eba\u306e\u8133MRI\u691c\u67fb\u3068\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08Genome-Wide Association Study [GWAS\uff08\u203b\uff12\uff09]\uff09\u3092\u884c\u3044\u3001\u5927\u8133\u767d\u8cea\u75c5\u5909\u5bb9\u7a4d\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u5ea7\u3092\u691c\u7d22\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u5927\u8133\u767d\u8cea\u75c5\u5909\u5bb9\u7a4d\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u5ea7\u3068\u3057\u306617\u756a\u67d3\u8272\u4f53\u306eGFAP\u907a\u4f1d\u5b50\u306e295\u756a\u76ee\u306e\u30a2\u30df\u30ce\u9178\u3092\u5909\u3048\u308b\u5909\u7570\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u82f1\u56fd\u306eUK\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\uff08\u203b3\uff09\u7814\u7a76\u306eGWAS\u30c7\u30fc\u30bf\u3068\u306e\u7d71\u5408\u89e3\u6790\u3092\u5b9f\u65bd\u3057\u305f\u7d50\u679c\u300120\u304b\u6240\u306e\u907a\u4f1d\u5b50\u5ea7\u304c\u5927\u8133\u767d\u8cea\u75c5\u5909\u5bb9\u7a4d\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u3046\u30616\u756a\u67d3\u8272\u4f53\uff08SLC2A12\u907a\u4f1d\u5b50\uff08\u203b4\uff09)\u306b\u5b58\u5728\u3059\u308b1\u304b\u6240\u306e\u907a\u4f1d\u5b50\u5ea7\u304c\u65b0\u898f\u306e\u907a\u4f1d\u5b50\u5ea7\u3067\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br \/>\n\u3000\u672c\u7814\u7a76\u6210\u679c\u306f\u30012024\u5e7411\u670813\u65e5\uff08\u6c34\uff09\u5348\u5f8c7\u6642\uff08\u65e5\u672c\u6642\u9593\uff09\u306b\u56fd\u969b\u5b66\u8853\u8a8cnpj Genomic Medicine\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n<span><br \/>\n\uff08\u203b1\uff09 \u5065\u5eb7\u9577\u5bff\u793e\u4f1a\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u305f\u5927\u898f\u6a21\u8a8d\u77e5\u75c7\u30b3\u30db\u30fc\u30c8\u7814\u7a76\uff1aJapan Prospective Studies Collaboration for Aging and Dementia\uff08JPSC-AD\uff09<br \/>\n\u6211\u304c\u56fd\u306e8\u5730\u57df\uff08\u9752\u68ee\u770c\u5f18\u524d\u5e02\u3001\u5ca9\u624b\u770c\u77e2\u5dfe\u753a\u3001\u77f3\u5ddd\u770c\u4e03\u5c3e\u5e02\u4e2d\u5cf6\u753a\u3001\u6771\u4eac\u90fd\u8352\u5ddd\u533a\u3001\u5cf6\u6839\u770c\u6d77\u58eb\u753a\u3001\u611b\u5a9b\u770c\u4f0a\u4e88\u5e02\u4e2d\u5c71\u753a\u3001\u798f\u5ca1\u770c\u4e45\u5c71\u753a\u3001\u718a\u672c\u770c\u8352\u5c3e\u5e02\uff09\u306b\u304a\u3051\u308b\u5730\u57df\u9ad8\u9f62\u4f4f\u6c11\u7d04\uff11\u4e07\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5927\u898f\u6a21\u8a8d\u77e5\u75c7\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u3042\u308b\uff08https:\/\/www.eph.med.kyushu-u.ac.jp\/jpsc\/\uff09\u3002<br \/>\n\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u8abf\u67fb\u306f2016\u5e74\uff0d2018\u5e74\u306b\u5b9f\u65bd\u3055\u308c\u3001\u4e88\u30818\u5730\u57df\u3067\u6a19\u6e96\u5316\u3055\u308c\u305f\u7814\u7a76\u8a08\u753b\u306b\u57fa\u3065\u3044\u3066\u3001\u8a73\u7d30\u306a\u81e8\u5e8a\u60c5\u5831\uff08\u8a8d\u77e5\u6a5f\u80fd\u3092\u542b\u3080\uff09\u3001\u982d\u90e8MRI\u753b\u50cf\u30c7\u30fc\u30bf\u3001\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u53ce\u96c6\u3057\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001\u8a8d\u77e5\u75c7\u3084\u5fc3\u8840\u7ba1\u75c5\u306e\u767a\u75c7\u3084\u6b7b\u4ea1\u306b\u95a2\u3059\u308b\u8ffd\u8de1\u8abf\u67fb\u3092\u7d99\u7d9a\u3057\u3066\u3044\u308b\u3002<\/p>\n<p> \uff08\u203b2\uff09 \u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff1aGenome-Wide Association Study\uff08GWAS\uff09<br \/>\n\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u5168\u57df\u306b\u5206\u5e03\u3059\u308b\u907a\u4f1d\u7684\u5909\u7570\u3068\u3001\u81e8\u5e8a\u691c\u67fb\u5024\u306a\u3069\u306e\u91cf\u7684\u306a\u5f62\u8cea\u3084\u75c5\u6c17\u3068\u306e\u56e0\u679c\u95a2\u4fc2\u3092\u7db2\u7f85\u7684\u306b\u691c\u8a0e\u3059\u308b\u907a\u4f1d\u7d71\u8a08\u89e3\u6790\u624b\u6cd5\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u6570\u767e\u3092\u8d85\u3048\u308b\u5f62\u8cea\u3084\u75c5\u6c17\u3092\u5bfe\u8c61\u306b\u5b9f\u65bd\u3055\u308c\u3001\u6570\u591a\u304f\u306e\u95a2\u9023\u907a\u4f1d\u7684\u5909\u7570\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>\uff08\u203b3\uff09 UK\u30d0\u30a4\u30aa\u30d0\u30f3\u30af<br \/>\n\u82f1\u56fd\u3067\u884c\u308f\u308c\u3066\u3044\u308b\u4e16\u754c\u6700\u5927\u898f\u6a21\u306e\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u3067\u3001\u7d0450\u4e07\u4eba\u306e\u53c2\u52a0\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001\u907a\u4f1d\u60c5\u5831\u3001\u75be\u60a3\u60c5\u5831\u3001\u8840\u6db2\u306a\u3069\u306e\u591a\u5f69\u306a\u60c5\u5831\u30fb\u8a66\u6599\u3092\u53ce\u96c6\u3057\u3066\u3044\u308b\u3002\u60c5\u5831\u306f\u4e16\u754c\u4e2d\u306e\u7814\u7a76\u8005\u306b\u63d0\u4f9b\u3055\u308c\u3001\u591a\u6570\u306e\u7814\u7a76\u7d50\u679c\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>\uff08\u203b4\uff09 SLC2A12\u907a\u4f1d\u5b50<br \/>\n\u7d30\u80de\u304c\u30d6\u30c9\u30a6\u7cd6\u306a\u3069\u306e\u7cd6\u3092\u53d6\u308a\u8fbc\u3080\u306e\u3092\u52a9\u3051\u308bGLUT12\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3002GLUT12\u306f\u8133\u5185\u306e\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p><span><br \/>\n<strong>\u4e8c\u5bae\u6559\u6388\u304b\u3089\u3072\u3068\u3053\u3068<\/strong><br \/>\n<span><br \/>\n\u672c\u7814\u7a76\u306e\u7d50\u679c\u306b\u3088\u308a\u3001\u6771\u30a2\u30b8\u30a2\u306e\u4eba\u306b\u3088\u304f\u898b\u3089\u308c\u308b\u907a\u4f1d\u5b50\u306e\u591a\u578b\u304c\u3001\u5927\u8133\u767d\u8cea\u75c5\u5909\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u8133\u5352\u4e2d\u3084\u8a8d\u77e5\u75c7\u306e\u30ea\u30b9\u30af\u306e\u63a8\u5b9a\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u4eca\u5f8c\u3001\u7570\u306a\u308b\u5730\u57df\u3084\u4eba\u7a2e\u3092\u5bfe\u8c61\u306b\u3057\u305f\u56fd\u969b\u7684\u306a\u5927\u898f\u6a21\u7814\u7a76\u3092\u5b9f\u65bd\u3059\u308b\u3053\u3068\u3067\u3001\u5927\u8133\u767d\u8cea\u75c5\u5909\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306e\u8a73\u7d30\u306a\u691c\u8a0e\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u5730\u57df\u3084\u751f\u6d3b\u74b0\u5883\u3001\u6587\u5316\u80cc\u666f\u306b\u3088\u308b\u5927\u8133\u767d\u8cea\u75c5\u5909\u306e\u907a\u4f1d\u7684\u5f71\u97ff\u306e\u9055\u3044\u304c\u660e\u3089\u304b\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br \/>\n<span><br \/>\n<span><br \/>\n<span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u672a\u6765\u793e\u4f1a\u30c7\u30b6\u30a4\u30f3\u7d71\u62ec\u672c\u90e8\u3001\u533b\u7642\u30fb\u5065\u5eb7\u30e6\u30cb\u30c3\u30c8\/\u793e\u4f1a\u5909\u9769\u578b\u30c7\u30fc\u30bf\u30b5\u30a4\u30a8\u30f3\u30b9\u3000\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\u3001 \u4e8c\u5bae\u5229\u6cbb\u6559\u6388\uff08\u533b\u5b66\u7814\u7a76\u9662\uff09\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u6210\u679c\u306b\u3064\u3044\u3066\u304a\u77e5\u3089\u305b\u3044\u305f\u3057\u307e\u3059\u3002 \u3000\u5927\u8133\u767d\u8cea\u75c5\u5909\u306f\u8133MRI\u753b\u50cf\u3067\u3088\u304f\u898b\u3089\u308c\u308b\u75c5\u5909 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":3069,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false},"categories":[4],"tags":[],"class_list":["post-3068","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-information","in2fs_unit_taxonomy-medicine-and-health"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/3068","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/comments?post=3068"}],"version-history":[{"count":9,"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/3068\/revisions"}],"predecessor-version":[{"id":3078,"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/3068\/revisions\/3078"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/media\/3069"}],"wp:attachment":[{"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=3068"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/categories?post=3068"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/wp-json\/wp\/v2\/tags?post=3068"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}