{"id":2602,"date":"2024-07-31T14:52:15","date_gmt":"2024-07-31T05:52:15","guid":{"rendered":"https:\/\/in2fs.kyushu-u.ac.jp\/?p=2602"},"modified":"2024-07-31T14:52:15","modified_gmt":"2024-07-31T05:52:15","slug":"researches1121","status":"publish","type":"post","link":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/news\/researches1121\/","title":{"rendered":"\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u54c1\u8cea\u3092\u7dad\u6301\u3059\u308b\u85ac\u304c\u7cd6\u5c3f\u75c5\u3084\u8102\u80aa\u809d\u3092\u6539\u5584\u3055\u305b\u308b"},"content":{"rendered":"<div class=\"u-show-for-ja\" lang=\"ja\" data-modified=\"2024-07-31\">\n\u672a\u6765\u793e\u4f1a\u30c7\u30b6\u30a4\u30f3\u7d71\u62ec\u672c\u90e8\u3001<a href=\"https:\/\/in2fs.kyushu-u.ac.jp\/unit\/medicine-and-health\/\/\">\u533b\u7642\u30fb\u5065\u5eb7\u30e6\u30cb\u30c3\u30c8\/\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u5275\u85ac\u30b0\u30eb\u30fc\u30d7<\/a>\u3000\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\u3001<br \/>\n<strong>\u897f\u7530\u57fa\u5b8f\u6559\u6388<\/strong>\uff08\u85ac\u5b66\u7814\u7a76\u9662\uff09\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u6210\u679c\u306b\u3064\u3044\u3066\u304a\u77e5\u3089\u305b\u3044\u305f\u3057\u307e\u3059\u3002<br \/>\n<span><br \/>\n\u3000\u7cd6\u5c3f\u75c5\u306f\u4e16\u754c\u4e2d\u306e\u6210\u4eba\u306e10\uff05\u8fd1\u304f\u304c\u7f79\u60a3\u3059\u308b\u6162\u6027\u4ee3\u8b1d\u75be\u60a3\u3067\u3059\u3002\u8eab\u4f53\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u30b0\u30eb\u30b3\u30fc\u30b9\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3068\u3057\u3066\u5229\u7528\u3055\u308c\u307e\u3059\u304c\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u7d44\u7e54\u3067\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u7570\u5e38\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5f62\u614b\u7570\u5e38\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u80fd\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u8cea\u306e\u7dad\u6301\uff08\u54c1\u8cea\u7ba1\u7406\uff09\u304c\u7cd6\u5c3f\u75c5\u306e\u826f\u3044\u6cbb\u7642\u6226\u7565\u306b\u306a\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u307e\u3057\u305f\u3002<br \/>\n\u3000\u672c\u7814\u7a76\u3067\u306f\u3001\u4ee5\u524d\u540c\u5b9a\u3057\u305f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u904e\u5270\u5206\u88c2\u3092\u6291\u5236\u3059\u308b\u9ad8\u8840\u5727\u6cbb\u7642\u85ac\u30b7\u30eb\u30cb\u30b8\u30d4\u30f3\u3092\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3078\u6295\u4e0e\u3057\u3001\u8840\u7cd6\u5024\u304c\u6539\u5584\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<br \/>\n\u3000\u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u9662\u306e\u897f\u7530\u57fa\u5b8f\u6559\u6388\uff08\u81ea\u7136\u79d1\u5b66\u7814\u7a76\u6a5f\u69cb\u751f\u7406\u5b66\u7814\u7a76\u6240 \/ \u751f\u547d\u5275\u6210\u63a2\u7a76\u30bb\u30f3\u30bf\u30fc\u517c\u52d9\uff09\u3001\u52a0\u85e4\u767e\u5408\u52a9\u6559\u3001\u6709\u5409\u822a\u5e73\u5927\u5b66\u9662\u751f\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u4eac\u90fd\u5927\u5b66\u3001\u5927\u962a\u516c\u7acb\u5927\u5b66\u306a\u3069\u3068\u5171\u540c\u3067\u3001\u30b7\u30eb\u30cb\u30b8\u30d4\u30f3\u304cDrp1\uff08\u203b1\uff09\u3068Filamin\uff08\u203b2\uff09\u3068\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u9593\u76f8\u4e92\u4f5c\u7528\u3092\u963b\u5bb3\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5f62\u614b\u7570\u5e38\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u3001\u8840\u7cd6\u5024\u3092\u6539\u5584\u3055\u305b\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u30b7\u30eb\u30cb\u30b8\u30d4\u30f3\u306f\u3001\u809d\u81d3\u306b\u304a\u3051\u308b\u8102\u80aa\u6ef4\uff08\u203b\uff13\uff09\u306e\u84c4\u7a4d\u3082\u8efd\u6e1b\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u540c\u90e8\u5c40\u306e\u738b\u5b50\u7530\u5f70\u592b\u6559\u6388\u3001\u5ddd\u897f\u82f1\u6cbb\u8b1b\u5e2b\u3089\u3068\u306e\u9023\u643a\u306b\u3088\u308a\u3001\u30b7\u30eb\u30cb\u30b8\u30d4\u30f3\u306e\u65e2\u77e5\u306e\u4f5c\u7528\uff08Ca2+\u30c1\u30e3\u30cd\u30eb\u963b\u5bb3\u6d3b\u6027\uff09\u3092\u9664\u53bb\u3057\u305f\u8a98\u5c0e\u4f53\uff081-4DHP\uff09\u3092\u540c\u5b9a\u3057\u30011,4-DHP\u304c\u30b7\u30eb\u30cb\u30b8\u30d4\u30f3\u3088\u308a\u52b9\u679c\u7684\u306b\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u30de\u30a6\u30b9\u306e\u9ad8\u8840\u7cd6\u3084\u8102\u80aa\u809d\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u767a\u898b\u306f\u7cd6\u5c3f\u75c5\u3001\u8102\u80aa\u809d\u306b\u9650\u3089\u305a\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5f62\u614b\u7570\u5e38\u3092\u4f34\u3046\u69d8\u3005\u306a\u75be\u60a3\u306b\u5bfe\u3059\u308b\u753b\u671f\u7684\u306a\u6cbb\u7642\u6cd5\u3092\u63d0\u6848\u3059\u308b\u3082\u306e\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br \/>\n\u3000\u672c\u7814\u7a76\u6210\u679c\u306f\u82f1\u56fd\u306e\u96d1\u8a8c\u300cBritish Journal of Pharmacology\u300d\u306b2024\u5e747\u670811\u65e5\uff08\u6728\uff09\uff08\u65e5\u672c\u6642\u9593\uff09\u3001\u30b9\u30a4\u30b9\u306e\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\u96d1\u8a8c\u300cInternational Journal of Molecular Science \u300d\u306b2024\u5e745\u670817\u65e5\uff08\u91d1\uff09\uff08\u65e5\u672c\u6642\u9593\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>(\u203b1) Drp1<br \/>\nDynamin-related protein1. \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u5206\u88c2\u306b\u5fc5\u9808\u306e\u56e0\u5b50\u3002<\/p>\n<p>(\u203b2) Filamin<br \/>\n\u7d30\u80de\u9aa8\u683c\u3092\u53f8\u308b\u30a2\u30af\u30c1\u30f3\u306b\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3002<\/p>\n<p>(\u203b3) \u8102\u80aa\u6ef4<br \/>\n\u7d30\u80de\u5185\u3067\u8102\u8cea\u3092\u8caf\u8535\u3057\u3066\u3044\u308b\u7d30\u80de\u5c0f\u5668\u5b98\u3002\u8102\u80aa\u6ef4\u306e\u84c4\u7a4d\u304c\u69d8\u3005\u306a\u75be\u60a3\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u672a\u6765\u793e\u4f1a\u30c7\u30b6\u30a4\u30f3\u7d71\u62ec\u672c\u90e8\u3001\u533b\u7642\u30fb\u5065\u5eb7\u30e6\u30cb\u30c3\u30c8\/\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u5275\u85ac\u30b0\u30eb\u30fc\u30d7\u3000\u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\u3001 \u897f\u7530\u57fa\u5b8f\u6559\u6388\uff08\u85ac\u5b66\u7814\u7a76\u9662\uff09\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u6210\u679c\u306b\u3064\u3044\u3066\u304a\u77e5\u3089\u305b\u3044\u305f\u3057\u307e\u3059\u3002 \u3000\u7cd6\u5c3f\u75c5\u306f\u4e16\u754c\u4e2d\u306e\u6210\u4eba\u306e10\uff05\u8fd1\u304f\u304c\u7f79\u60a3\u3059\u308b\u6162\u6027 [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":2604,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false},"categories":[4],"tags":[],"class_list":["post-2602","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-information","in2fs_unit_taxonomy-medicine-and-health"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"\u672a\u6765\u793e\u4f1a\u30c7\u30b6\u30a4\u30f3\u7d71\u62ec\u672c\u90e8\u3001\u533b\u7642\u30fb\u5065\u5eb7\u30e6\u30cb\u30c3\u30c8\/\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u5275\u85ac\u30b0\u30eb\u30fc\u30d7 \u30b0\u30eb\u30fc\u30d7\u30ea\u30fc\u30c0\u30fc\u3001 \u897f\u7530\u57fa\u5b8f\u6559\u6388\uff08\u85ac\u5b66\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" 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