{"id":2577,"date":"2024-07-26T13:02:39","date_gmt":"2024-07-26T04:02:39","guid":{"rendered":"https:\/\/in2fs.kyushu-u.ac.jp\/?p=2577"},"modified":"2024-07-26T13:34:07","modified_gmt":"2024-07-26T04:34:07","slug":"researches1104","status":"publish","type":"post","link":"https:\/\/in2fs.kyushu-u.ac.jp\/en\/news\/researches1104\/","title":{"rendered":"\u539f\u767a\u958b\u653e\u9685\u89d2\u7dd1\u5185\u969c\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u63a8\u5b9a\u6cd5\u3092\u958b\u767a"},"content":{"rendered":"
\n\u672a\u6765\u793e\u4f1a\u30c7\u30b6\u30a4\u30f3\u7d71\u62ec\u672c\u90e8\u3001\u533b\u7642\u30fb\u5065\u5eb7\u30e6\u30cb\u30c3\u30c8\/\u793e\u4f1a\u5909\u9769\u578b\u30c7\u30fc\u30bf\u30b5\u30a4\u30a8\u30f3\u30b9\u30b0\u30eb\u30fc\u30d7<\/a>\u3000\u30b0\u30eb\u30fc\u30d7\u30b0\u30eb\u30fc\u30d7\u30e1\u30f3\u30d0\u30fc\u3001
\n\u79cb\u5c71\u96c5\u4eba\u8b1b\u5e2b<\/strong>\uff08\u533b\u5b66\u7814\u7a76\u9662\uff09\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u6210\u679c\u306b\u3064\u3044\u3066\u304a\u77e5\u3089\u305b\u3044\u305f\u3057\u307e\u3059\u3002
\n
\n\u3000\u73fe\u5728\u3001\u65e5\u672c\u306e\u8996\u899a\u969c\u5bb3\u306e\u539f\u56e0\u3067\u6700\u3082\u591a\u3044\u306e\u306f\u7dd1\u5185\u969c\u3067\u3042\u308a\u3001\u539f\u767a\u958b\u653e\u9685\u89d2\u7dd1\u5185\u969c\u304c\u4e3b\u8981\u306a\u75c5\u578b\u3067\u3059\u3002\u773c\u5727\u3084\u8fd1\u8996\u306a\u3069\u773c\u79d1\u7684\u306a\u8981\u56e0\u306b\u52a0\u3048\u3066\u3001\u907a\u4f1d\u7684\u306a\u8981\u56e0\u304c\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u5831\u544a\u8005\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u539f\u767a\u958b\u653e\u9685\u89d2\u7dd1\u5185\u969c\u306e\u306a\u308a\u3084\u3059\u3055\u306b\u95a2\u308f\u308b\u30b2\u30ce\u30e0\u4e0a\u306e\u611f\u53d7\u6027\u9818\u57df\u3092\u3053\u308c\u307e\u3067\u306b\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u75be\u60a3\u767a\u75c7\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u5341\u5206\u306b\u691c\u8a3c\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002
\n\u3000\u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662\u773c\u75c5\u614b\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u8b1b\u5ea7\u306e\u79cb\u5c71\u96c5\u4eba\u8b1b\u5e2b\u3001\u773c\u79d1\u5b66\u5206\u91ce\u306e\u85e4\u539f\u5eb7\u592a\u52a9\u6559\u3001\u5712\u7530\u5eb7\u5e73\u6559\u6388\u3001\u885b\u751f\u30fb\u516c\u8846\u885b\u751f\u5b66\u5206\u91ce\u306e\u4e8c\u5bae\u5229\u6cbb\u6559\u6388\u3001\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1\u773c\u79d1\u5b66\u5206\u91ce\u306e\u4e2d\u6fa4\u5fb9\u6559\u6388\u3001\u6771\u5317\u5927\u5b66\u6771\u5317\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30e1\u30ac\u30d0\u30f3\u30af\u6a5f\u69cb\u30b2\u30ce\u30e0\u89e3\u6790\u90e8\u9580\u306e\u7530\u5bae\u5143\u6559\u6388\u3001\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u65b0\u9818\u57df\u5275\u6210\u79d1\u5b66\u7814\u7a76\u79d1\u8907\u96d1\u5f62\u8cea\u30b2\u30ce\u30e0\u89e3\u6790\u5206\u91ce\u306e\u938c\u8c37\u6d0b\u4e00\u90ce\u6559\u6388\u3089\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u500b\u4eba\u306e\u539f\u767a\u958b\u653e\u9685\u89d2\u7dd1\u5185\u969c\u306e\u907a\u4f1d\u7684\u306a\u306a\u308a\u3084\u3059\u3055\u3092\u6570\u5024\u5316\u3059\u308b\u624b\u6cd5\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u307f\u307e\u3057\u305f\u3002
\n\u3000\u6771\u5317\u5927\u5b66\u304c\u53ce\u96c6\u3057\u305f\u60a3\u8005-\u5bfe\u7167\u30b5\u30f3\u30d7\u30eb\u3092\u7528\u3044\u3066\u8907\u6570\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u8a08\u7b97\u6cd5\u306e\u7cbe\u5ea6\u3092\u691c\u8a3c\u3057\u305f\u3068\u3053\u308d\u3001\u56fd\u969b\u30b3\u30f3\u30bd\u30fc\u30b7\u30a2\u30e0\u304c\u5831\u544a\u3057\u305f127\u306e\u907a\u4f1d\u7684\u5909\u7570\u306e\u3046\u3061\u3001\u6771\u4eac\u5927\u5b66\u533b\u79d1\u5b66\u7814\u7a76\u6240\u306e\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u30fb\u30b8\u30e3\u30d1\u30f3(\u203b1)\u306e\u7814\u7a76\u53c2\u52a0\u8005\u3067\u5b9f\u65bd\u3055\u308c\u305f\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790(\u203b2) (GWAS)\u306e\u7d50\u679c\u304c\u53c2\u7167\u53ef\u80fd\u306a98\u306e\u907a\u4f1d\u7684\u5909\u7570\u306b\u57fa\u3065\u304d\u7b97\u51fa\u3057\u305f\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u8a08\u7b97\u6cd5\u304c\u6700\u3082\u512a\u308c\u305f\u5224\u5225\u80fd\u3092\u793a\u3057\u307e\u3057\u305f (\u53d7\u4fe1\u8005\u52d5\u4f5c\u7279\u6027 [ROC]\u66f2\u7dda\u4e0b\u9762\u7a4d: 0.65)\u3002\u3053\u306e\u7d50\u679c\u306f\u3001\u65e5\u672c\u7dd1\u5185\u969c\u5b66\u4f1a\u907a\u4f1d\u5b50\u95a2\u9023\u7814\u7a76\u73ed\u3068\u65e5\u672c\u773c\u79d1\u5b66\u4f1a \u30b2\u30ce\u30e0\u7814\u7a76\u59d4\u54e1\u4f1a\uff08\u203b3\uff09\u306b\u3088\u308a\u53ce\u96c6\u3055\u308c\u305f\u60a3\u8005-\u5bfe\u7167\u30b5\u30f3\u30d7\u30eb\u3067\u3082\u3001\u540c\u7b49\u306e\u6027\u80fd\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f (ROC\u66f2\u7dda\u4e0b\u9762\u7a4d: 0.64)\u3002\u907a\u4f1d\u7684\u306a\u30ea\u30b9\u30af\u304c\u4e0b\u4f4d10%\u3068\u4e0a\u4f4d10%\u306b\u5206\u985e\u3055\u308c\u308b\u65b9\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u60a3\u8005\u3068\u5bfe\u7167\u306e\u5272\u5408\u306b\u306f\u5927\u304d\u306a\u9055\u3044\u304c\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f (\u30aa\u30c3\u30ba\u6bd4: 6.15)\u3002\u3053\u3053\u307e\u3067\u306e\u89e3\u6790\u306f\u4e3b\u306b\u5927\u5b66\u75c5\u9662\u3092\u53d7\u8a3a\u3057\u305f\u6bd4\u8f03\u7684\u91cd\u75c7\u306a\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u305f\u305f\u3081\u3001\u958b\u767a\u3055\u308c\u305f\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u63a8\u5b9a\u6cd5\u306b\u3064\u3044\u3066\u3001\u4e5d\u5dde\u5927\u5b66\u304c\u5b9f\u65bd\u3057\u3066\u3044\u308b\u75ab\u5b66\u7814\u7a76\u3067\u3042\u308b\u4e45\u5c71\u753a\u7814\u7a76\u3067\u53d6\u5f97\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3067\u3082\u691c\u8a3c\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u3001\u4e00\u822c\u4f4f\u6c11\u306b\u304a\u3044\u3066\u3082\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u4e0b\u4f4d20%\u3068\u4e0a\u4f4d20%\u306b\u5206\u985e\u3055\u308c\u308b\u65b9\u3067\u306f\u3001\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u7fa4\u3067\u60a3\u8005\u306e\u5272\u5408\u304c\u591a\u3044\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u7dd1\u5185\u969c\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u4f4f\u6c11\u306b\u304a\u3044\u3066\u3001\u539f\u767a\u958b\u653e\u9685\u89d2\u7dd1\u5185\u969c\u306e\u907a\u4f1d\u7684\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u306f\u3001\u773c\u5727\u304c\u9ad8\u304f\u8996\u795e\u7d4c\u4e73\u982d\u9665\u51f9\u6bd4\u304c\u5927\u304d\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u7814\u7a76\u6210\u679c\u306b\u3088\u308a\u3001\u65e5\u672c\u4eba\u306b\u304a\u3044\u3066\u539f\u767a\u958b\u653e\u9685\u89d2\u7dd1\u5185\u969c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306e\u5224\u5b9a\u304c\u907a\u4f1d\u60c5\u5831\u304b\u3089\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u6210\u679c\u306f\u3001\u4e00\u4eba\u4e00\u4eba\u306e\u907a\u4f1d\u7684\u306a\u7dd1\u5185\u969c\u306e\u306a\u308a\u3084\u3059\u3055\u306e\u9055\u3044\u306b\u5fdc\u3058\u305f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u691c\u67fb\u3084\u767a\u75c7\u4e88\u9632\u306b\u5f79\u7acb\u3064\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002
\n\u3000\u672c\u7814\u7a76\u6210\u679c\u306f\u7c73\u56fd\u306e\u96d1\u8a8c\u300cOphthalmology\u300d\u306b2024\u5e74\uff17\u670818\u65e5\uff08\u6728\uff09\uff08\u65e5\u672c\u6642\u9593\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

(\u203b1) \u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u30fb\u30b8\u30e3\u30d1\u30f3
\n\u6771\u4eac\u5927\u5b66\u533b\u79d1\u5b66\u7814\u7a76\u6240\u306b\u8a2d\u7f6e\u3055\u308c\u305f\u30a2\u30b8\u30a2\u6700\u5927\u898f\u6a21\u306e\u751f\u4f53\u8a66\u6599\u30d0\u30f3\u30af\u3067\u3001\u7d0427\u4e07\u4eba\u306e\u7814\u7a76\u53c2\u52a0\u8005\u304b\u3089\u53ce\u96c6\u3057\u305f\u81e8\u5e8a\u60c5\u5831\u306b\u52a0\u3048\u3001DNA\u3084\u8840\u6e05\u30b5\u30f3\u30d7\u30eb\u3092\u4fdd\u7ba1\u3057\u3001\u7814\u7a76\u8005\u3078\u306e\u8a66\u6599\u3084\u30c7\u30fc\u30bf\u306e\u63d0\u4f9b\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n

(\u203b2) \u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790 (Genome-wide association study; GWAS)
\n2002\u5e74\u306b\u7406\u5316\u5b66\u7814\u7a76\u6240\u304c\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u5831\u544a\u3057\u305f\u30b2\u30ce\u30e0\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u3002\u75c5\u6c17\u306e\u306a\u308a\u3084\u3059\u3055\u306a\u3069\u69d8\u3005\u306a\u500b\u4eba\u306e\u9055\u3044\u306b\u95a2\u4fc2\u304c\u3042\u308b\u30b2\u30ce\u30e0\u4e0a\u306e\u9818\u57df\u3092\u7279\u5b9a\u3059\u308b\u624b\u6cd5\u3002<\/p>\n

(\u203b3) \u65e5\u672c\u773c\u79d1\u5b66\u4f1a \u30b2\u30ce\u30e0\u7814\u7a76\u59d4\u54e1\u4f1a (GRC-JOS)
\n\u65e5\u672c\u773c\u79d1\u5b66\u4f1a\u304c\u3001\u773c\u79d1\u9818\u57df\u306e\u30b2\u30ce\u30e0\u7814\u7a76\u306e\u63a8\u9032\u3092\u76ee\u7684\u306b\u8a2d\u7acb\u3057\u305f\u59d4\u54e1\u4f1a\u3002\u73fe\u5728\u3001\u591a\u304f\u306e\u773c\u79d1\u6a5f\u95a2\u306e\u5354\u529b\u3092\u5f97\u3066\u3001\u7814\u7a76\u8005\u9593\u3067\u5171\u6709\u304c\u53ef\u80fd\u306a\u5bfe\u7167\u7fa4\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u306e\u69cb\u7bc9\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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